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Clinical Efficacy of Glutathione Supplementation in PCOS

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by hormonal imbalances, irregular menstrual cycles, and the presence of cysts on the ovaries. One of the key factors in the development of PCOS is oxidative stress, which can lead to inflammation and insulin resistance.

What is Glutathione?

Glutathione is a powerful antioxidant that plays a crucial role in protecting cells from damage caused by oxidative stress. It is produced naturally in the body and is involved in various processes, including detoxification, immune function, and DNA repair. However, in conditions of increased oxidative stress, such as PCOS, the body may require additional support in the form of glutathione supplementation.

How Does Glutathione Help in PCOS?

Studies have shown that women with PCOS often have lower levels of glutathione compared to healthy individuals. By supplementing with glutathione, individuals with PCOS may be able to reduce oxidative stress, improve insulin sensitivity, and regulate their menstrual cycles. Additionally, glutathione has been found to have anti-inflammatory properties, which can help alleviate symptoms associated with PCOS.

Clinical Efficacy of Glutathione Supplementation

A systematic review and meta-analysis published in the Journal of Clinical Endocrinology & Metabolism found that glutathione supplementation was associated with improvements in insulin sensitivity and markers of oxidative stress in women with PCOS. The study concluded that glutathione may be a promising adjunct therapy for managing PCOS and its associated complications.

Another study published in the European Journal of Obstetrics & Gynecology and Reproductive Biology reported that glutathione supplementation led to a significant reduction in inflammatory markers and improvements in menstrual regularity in women with PCOS. These findings suggest that glutathione may have a beneficial impact on the underlying mechanisms of PCOS.


While more research is needed to fully understand the role of glutathione supplementation in managing PCOS, the existing evidence suggests that it may offer potential benefits for women with this condition. By reducing oxidative stress, improving insulin sensitivity, and addressing inflammation, glutathione supplementation could be a valuable addition to the treatment approach for PCOS. Consult with a healthcare provider before starting any new supplement regimen, especially if you have a medical condition like PCOS.

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